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Accupril (Quinapril Hydrochloride)


Accupril is the brand name for the generic drug quinapril hydrochloride. Accupril is used in the treatment of hypertension and heart failure. In the treatment of heart failure it is used along with other medications for that treatment. In the case of treating hypertension, it can be used alone or with other thiazide diuretics. Accupril is available in the form of tablets in strengths of 5 mg, 10 mg, 20 mg and 40 mg in bottles of 90 tablets.

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In treating hypertension without diuretics, the recommended dosage is 10 mg or 20 mg once daily. The response of the patient after 2 to 6 hours is checked and the dosage can be adjusted. Dosage adjustments are made at intervals of two weeks only. Some patients might require up to 80 mg per day as single or divided doses. When the patient is treated along with diuretics then the blood pressure should be monitored for several hours initially to see the response and the dosages adjusted.

For patients with renal impairment the creatinine clearance levels are monitored and the dosage is given accordingly. If the creatinine clearance level is more than 60 mL/min then dosage of 10 mg of Accupril can be given. If it is between 30 to 60 mL/min, 5 mg is recommended and if it is between 10 to 30 mL/min, 2.5 mg is recommended.

In case of treating heart failure with other medications, the initial dosage of Accupril is 5 mg twice daily. If the initial dosage is tolerated by the patient then it can be increased at weekly intervals until an effective dose is reached. The maximum dose that can be reached is up to 40 mg divided into two equal doses.


If you experience any serious side effects like light-headedness, chill, severe blistering, chest pain, rapid weight gain, jaundice, or urinating more than usual, then you have to contact your doctor immediately. Less serious side effects like muscle pain, dizziness, headache, nausea, diarrhea, and cough might also occur. Interactions with other drugs might also occur. So it is better to inform your doctor if you are taking gold injections, lithium, potassium supplement, tetracycline, and diuretics.

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