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Actoplus Met (Metformin)


Actoplus Met is an anti-diabetic drug, particularly used for the treatment of type 2 diabetes. Actoplus Met contains two active components – pioglitazone hydrochloride and metformin hydrochloride. Both of these substances were previously approved for concomitant use in type 2 diabetes patients. They were tested on clinical trials, which featured patients that had type 2 diabetes, which didn’t respond properly on metformin treatment.

Actoplus Met is a combination of two anti-hyperglycemic substances with different mechanisms of action to help type 2 diabetes patients control their condition. They are pioglitazone hydrochloride, which is a thiazolidinedione class member, and metformin hydrochloride, coming from biguanides. Thiazolidinediones improve peripheral assimilation of glucose, while biguanides primarily decrease endogenous production of hepatic glucose.

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Choosing the initial Actoplus Met dosage should base on the current metformin and/or pioglitazone regimen of the patient. Patients should be closely observed after initiation of Actoplys Met for adverse reactions. The medication should be administered daily in divided doses during meals to lower the gastrointestinal side effects related to metformin.

Patients, who inadequately responded to metformin therapy, have to start off with 15 mg of pioglitazone and 500-850 mg of metformin once or twice daily. All the alterations should be conducted by your doctor, according to the therapy’s adequacy.

Patients, who adequately responded to pioglitazone therapy, but require additional glycemic control, should start taking 15 mg/500 mg two times a day or a 15 mg/850 mg dosage one time a day. All the changes should be held by your doctor, according to the therapy’s results.

The maximum recommended dose for pioglitazone is 45 mg a day, whereas the maximum advised daily metformin dosage is 2550 mg.


Actoplus Met is a very strong anti-diabetic drug. There is a number of conditions, about which you need to inform your doctor before getting prescribed with the medicine.

Contraindications for the use of Actoplus Met include the following:

- Hypersensitivity to the drug’s components;
- Type 1 pancreatic diabetes;
- Moderate and severe heart failure;
- Recent episodes of a shock, heart attack, or stroke;
- Infection;
- Low oxygen levels in the blood;
- Liver or kidney diseases;
- High levels of ketone or acid in the blood, and a few others.

Make sure to inform your doctor if you have any of the abovementioned conditions

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