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Adalat is referred to the drug class designed to control blood pressure. The pharmacological action of preparation falls to a group of ‘slow’ calcium channels blockers. The preparation’s active ingredient is represented by nifedipine. The drug has a strongly marked antihypertensive, antianginal and vasodilator action. Adalat is applied to lower blood pressure, achieve strong vasodilatation effect and prevent the onset of relief of angina attacks. The main active ingredient contributes to the reduction in the movement of potassium ions in the intracellular environment through calcium channels, which reduces peripheral vascular resistance and coronary arteries dilate.
Adalat: indications for use
The Adalat treatment is instructions prescribed in the treatment of the following diseases and as a part of complexes of treatment measures:
• arterial hypertension
• stenocardia (stable/unstable vasospastic, stable without vasoconstriction)
• Raynaud's disease and Raynaud's syndrome
• hypertensive crisis (mild forms)
• coronary arteries spasms
• for diagnostic or therapeutic intervention - coronary artery bypass grafting , percutaneous transluminal coronary angioplasty, vascular recanalization
• hypertension in the pulmonary circulation
The medication provides reduction in the tone of smooth muscles of coronary arteries, which assists in preventing vasoconstriction and increased oxygen delivery to the myocardium. Under the influence of nifedipine, arteriolar smooth muscle tone and blood pressure are reduced, though at the beginning of the application the heart rate and the amount of outputted liquid and sodium from the body may be increased.
Adalat is produced in the form of solution for infusion, tablets, capsules and oral drops. Adalat in the form of tablets (coated pills or capsules) designed with controlled release of active substance.
Those suffering from hypersensitivity to the components of the preparation and dihydropyridine derivatives must avoid taking the medicament. The contraindications to this drug are the following:
• hypotension accompanied by systolic pressure below 90 mm Hg. Art.
• cardiogenic shock
• simultaneous reception of the rifampicin-based preparations
• Ileostomy, established after proctocolectomy
• pregnancy and lactation periods in women
• the patients under 18 years old are not recommended to take Adalat
Under medical supervision, Adalat is prescribed in case of acute myocardial infarction, subaortic stenosis, severe aortic stenosis, heart failure, stenosis of the gastrointestinal tract, light hypotension, stroke severe stage, liver failure and severe bradycardia. The preparation must be used carefelly in elderly patients and those on gemodiaize courses.
Adalat is typically produced in the form of pills, capsules and tablets; prescribed to be taken orally with a little water. Administering the drug does is not affected by food intakes. The duration of therapy as well as the dosage of the drug is set individually. At the beginning of treatment course, the medication is administered in small doses, following a gradual increase. In case of angina or hypertension, the Adalat dosage typically equals 30 mg on a daily basis. With insufficient therapeutic effect of the dosage is increased to 60 mg per day. The maximum dose of the drug solution, administered by intravenous infusion, must not exceed 150-300 ml per day.
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