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The main ingredients of Avandaryl are glimepiride and rosiglitazone maleate and this oral mediacation is available in following strengths 4 mg/1 mg, 4 mg/2 mg, 4 mg/4 mg, 8 mg/2 mg, and 8 mg/4 mg. This is a specific drug for treating people with type-2 diabetes who do not use daily insulin injections. Each tablet of Avandaryl is triangular in shape.
Avandaryl should be started at the lowest recommended dose. Further increase in the dosage may be performed by looking into the adverse events related to fluid retention. The starting dosage would be 4 mg/1 mg. Rosiglitazone – 8 mg and glimepiride.- 4 mg is the maximum daily recommended dose of a person suffering from Type-2 diabetes. The storage temperature should not exceed 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F). The tabs are dispensed in a light-resistant and tight container.
Avandaryl should be taken with the first meal of the day. Patients with renal problem will take glimepiride-rosiglitazone combination @ 1 mg-4 mg and carefully titrated.
Before start of the treatment, the liver function tests should be carried out to find the serum transaminase level. Increase in two fold during therapy or at the initial stage should be consulted immediately with your health care provider to find out the cause for the elevation of liver enzyme. The treatment can be continued with close clinical monitoring of liver enzymes. The dose rate for these patients ranges from 1 mg-4 mg.
You should call the doctor immediately if you have experienced any of the following symptoms after continuous usage of Avandaryl: swelling of your face, lips, tongue, or throat; dyspnea, hives. The other serious side effects of this drug include chest pain or feeling heavy, vision problems etc. The continuous usage of this drug leads to Diabetes Retinopathy.
The usage of Avandaryl should be considered in malnourished and elderly patients with adrenal or renal or hepatic insufficiency.
It is highly recommended to assess the liver enzyme to rule out any hepatic problem before start of this drug therapy. The usage of Avandaryl is contraindicated in nursing and pregnant mothers. There is high incidence of cardio-vascular mortality with the continuous use of this drug. Other heart ailments associated with the continuous administration of this drug include Myocardial infarction, abdominal edema, etc.
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