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Beconase AQ (Beclomethasone Dipropionate)

Description

Beconase AQ spray is a hormonal drug, designed for inhalation to affect the mucosa of the respiratory organs. The main active ingredient of the medication is beclomethasone dipropionate, which causes inflammatory, anti-exudative, decongestants and anti-allergic properties Beclometasone. This drug is used as a means of basic therapy for bronchial asthma. Under the influence of beclomethasone dipropionate a reduction in the number of mast cells in bronchial mucosa (accumulate where most likely encounter with pathogens medium), inhibition of macrophage migration, exciting and digesting bacteria, the remains of dead cells, foreign and toxic for the body of the particle.

The drug’s action is aimed at reducing the edema of the epithelium, mucus secretion of bronchial glands, accumulation of neutrophils boundary, bronchial hyperreactivity and inflammatory exudate. The medication has a positive impact on respiratory function, although the fact should be underlined it does not relieve asthma attacks. Thus the noteworthy effect from the drug’s use is noted 5-7 days after the start of regular use. The inhalation method implies no systemic activity. 10-20% of a single dose enter the lungs, when released into the gastrointestinal tract the active ingredient is inactivated by the liver. With any method of use of the drug is excreted within four days in feces (mostly) and urine (10-15%).

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Indications

According to the annotation, the preparation is indicated for those suffering from asthma (inhalation use); prevention and treatment of allergic rhinitis, including rhinitis, and vasomotor rhinitis with hay fever (nose after application); infectious and inflammatory diseases of ears and the skin, applied in combination with antimicrobial agents (external and topical application).

Administration regimen

The drug is available in the form of spray (the same active ingredient may form the powder for inhalation drugs). The drug is prescribed for use in the following doses: 2-4 times a day and daily dose not more than 1mcg (2 mg in very severe cases); 50-100mcg, 2 to 4 times per day in children.

Intranasal administration: the spray is prescribed to adults and children 12+ years old for 3-4 times uses per day at 100 mcg into each nasal passage without exceeding 1 mg daily dose; children from 6 to 12 years are prescribed 50 micrograms into each nasal passage (but not more than 500 mg a day) with the same number of intakes as adults. A more precise dosing regimen and duration of treatment is determined by a physician.

Side effects

The spray, as well as the preparation in the of powder, may cause undesirable reactions, such as sneezing, coughing, irritation in the throat, dysphonia; rarely it causes paradoxical bronchospasm (eliminated through inhaled bronchodilators), eosinophilic pneumonia; candidiasis of upper respiratory tract and oral cavity; long-term use at high doses dizziness, headaches, increased intraocular pressure, cataract, lymphopenia, eosinopenia, leukocytosis; by intranasal application nosebleeds, rhinitis, nasal septum perforation, atrophy of the mucosa; the occasional use of more than 1 mg of beclomethasone dipropionate dysfunction of the hypothalamic-pituitary-adrenal axis; allergic reactions. The drug is contraindicated for use in children under 6 years and during the first trimester of pregnancy. Women on the second and third trimesters of pregnancy and nursing are prescribed the drug in case feasibility of use is approved by a treating physician. Caution is required when using the drug is used in people who had recent myocardial infarction, shortly operations in the nasal cavity and nose injuries.

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