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Bupron SR (Bupropion)


Bupron SR is unusual modern antidepressant with high pharmacological safety. Bupron SR has nonstandard mechanism of the action and is the only representative of the antidepressant group of the selective reuptake inhibitors of noradrenaline and dopamine.

Bupropion has been approved by FDA for the treatment of the depressive disorders. In the course of the studies of the active ingredients of Bupron SR it has been indicated that they inhibit nicotine receptors influencing on the nicotine craving.

Bupron SR is classified as psychostimulant but not as antidepressant in many medical sources. Indeed, this drug has a general stimulating and psychoenergetic action. As to the type of the action, Bupropion is similar to amphetamines except having narcotic properties.

Using Bupron SR patients state a good tolerance and absence of the typical side effects for the antidepressants. For example, using this drug, sexual dysfunction does not appear in comparison with common tricyclic antidepressants.

“SR” means that this drug has a prolonged action. As a rule, Bupropion is taken once a day, and the therapeutic effect of a pill is kept within 24 hours.

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Directions for the use

Bupron SR is prescribed for the treatment and prophylaxis of:

- Depression

- Anxious disorders

- Panic attacks

- Nicotine addiction

- Phobia

- Attention deficit/hyperactivity disorder

- Seasonal affective disorders

Bupron SR is prescribed for monotherapy of the depressive disorders because the interaction with other antidepressants may cause overdose and appearance of severe side effects.


The dosage regimen of Bupropion should be prescribed individually for depression or other mental disorders on the basis of the complete examination of the patient and clinical image of the disease.

- The treatment is started from the minimal dose of Bupron SR 150 mg a day

- Bupron SR 150 mg should be used every day, at the same time, with a full glass of water.

The antidepressive effect is slowly developed within 1-2 weeks. Therefore, if you do not feel the improvement of the health condition, it does not mean that the drug does not work.

In case of the acute conditions of the depressive or anxious disorders, it is allowed to increase the dose up to 300 mg of Bupropion per day. The everyday dose should be divided into 2 equal parts and a pill of Bupron SR 150 mg is taken in the morning and evening.

Bupron SR may be used if the patient has no contraindications for the use:

- Tumor of the brain in the active phase

- Convulsive activity of brain

- Epilepsy

- Suicidal thoughts

- Intolerance of Bupropion

If the patient takes monoamine oxidase inhibitors, the use of Bupron SR is in 2 weeks after the termination of that drug use. Patients with arterial hypertension and chronic liver diseases should be very cautious during the use of Bupropion.

Side effects

In rare cases, the use of Bupron SR may cause some side effects:

- Anxiety

- Sleep disorder

- Spasms

The appearance of the side effects of the digestion organs may be prevented by taking the pills after meals.

Bupron SR in high doses may cause epileptic attacks in patients with high aptitude to epilepsy. The side effects of Bupropion also include low appetite. Affecting certain receptors in the brain, this antidepressant significantly reduces appetite. Therefore, it is contraindicated during anorexia.

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