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Colospa (Mebeverine)


Colospa (Mebeverine) is a musculotropic spasmolytic. It works by relaxing smooth muscle tissue of the gastrointestinal tract (particularly that of the colon) relieving abdominal cramping associated with either irritable bowel syndrome* directly or any other organic disorder (e.g., regional enteritis, gastric/duodenal ulcers, dysentery, etc.) that among other symptoms involves flatulence, spasm, and pain.

*Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder, major symptoms of which include chronic abdominal pain (cramping), discomfort, bloating, and abnormal, usually alternate, bowel movements (diarrhea or constipation).

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Colospa (Mebeverine) is an over-the-counter medicine. This, however, does not mean that you can self-medicate. Firstly, you can hardly know for sure that it is the irritable bowel syndrome (primary or associated) that causes trouble. Secondly, you'll know neither therapeutic dose required in your case nor the duration of the treatment with the drug. Both you and your doctor should agree on Colospa as the best option before you go for the drug.

Having got a recommendation for Colospa, take it directly as indicated. Usually, the therapeutic dose of 135 mg is taken 3 times a day, roughly 20 minutes before each meal. Do not adjust the dosage (increase or decrease) without doctor's approval; only he/she will know when the produced effect is enough to start gradual reduction in dosing. Additionally, do not break the tablet or crush it, take it whole not to reduce its therapeutic efficacy.

Precautions and Contraindications

Colospa (Mebeverine) should be taken with caution by the patients that have the following diseases: porphyrias (inherited blood diseases), heart block and any liver and kidney impairment. It is not recommended to take the drug during pregnancy and breastfeeding, except the cases when the expected benefit outweighs the risk.

Administration of Colospa (Mebeverine) to patients with paralytic ileus (obstruction in the part of the intestine caused by failure of its function) is contraindicated. The drug may be also contraindicated in severe cases of conditions that usually come under the precautions category. Here you doctor is to assess the overall therapeutic relevance.

Drug Interactions

Generally drug interactions either result in adverse reactions or reduce the effectiveness of the medicines combined. The only known drug interaction that can potentially cause additive side effects is that of Colospa (Mebeverine) combined with another antispasmodic Buscopan. No any other potentially additive drug interaction has been reported.

Still, you have to fully inform the doctor in charge on any prescription/OTC/herbal medication currently taken.

Side Effects

Similarly to all other medicines, Colospa (Mebeverine) can affect different people in different ways. There can be common hypersensitivity and any individual bizarre reaction that is referred to as idiosyncrasy in pharmacology. Inform your health care provider about any unusual reaction to Mebeverine, an active ingredient of the drug, and antispasmodics on the whole if you have ever had any.

Common side effects associated with Colospa (Mebeverine) include discomfort in the upper abdomen (indigestion, heartburn), nausea, loss of appetite, constipation, dizziness, confusion, headache, insomnia, rash, itchy skin, decreased heart beat, tiredness. Side effects are usually dose related (obviated by dose reducing) and temporary (disappear with therapy discontinuation).

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