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Fusidic acid is referred to the class of bacteriostatic antibiotics. The medication is particularly strong against staphylococci, resistant to penicillin, streptomycin, chloramphenicol, erythromycin and other antibiotics. The preparation is less active against pneumococci and streptococci. Fusidic acid in the form sodium salt is an antibiotic designed to treat infections caused by strains of staphylococci resistant to penicillin and other antibiotics.
Fusidic acid has been called into existence in the year of 1960 in Denmark and since then it has been applied in treatment both system and superficial infections. Moreover, the preparation can be applied as an alternative remedy in treatment non-staphylococci diseases: the preparation is well tolerated and has a low level of toxicity and a small percentage of allergic reactions emergence.
Fusidic acid: indications for use
The drug demonstrates clinically proven efficiency in treating severe bacterial infections caused by susceptible to fusidic acid microorganisms, including sepsis, osteomyelitis, septic endocarditis, pneumonia, lung abscess, empyema and wound infections.
The medication in the form of cream represents a powerful remedy for treatment of dermatoses, inflammatory genesis with concomitant bacterial infection or a high probability of its layers, such as diffuse neurodermatitis, discoid eczematous dermatitis, radiation dermatitis, photodermatitis, seborrheic dermatitis, contact dermatitis, contagious impetigo erythrasma, lichen planus, psoriasis (except for its common form of plaque – psoriasis vulgaris) and discoid lupus erythematosus.
Dosage and administration methods
Adults with moderate infections are typically prescribed 0.5g of medication 3 times a day. In severe disease during the first 1-2 days the dosage may equal 2-3g/day, in process of time the dose may be reduced to normal. An average duration of treatment equals 7-14 days; in osteomyelitis cases – 2-3 weeks.
Children are typically appointed the average daily dose of 40-60 mg per 1 kg of body weight; in severe disease – up to 80 mg/kg.
Cream/gel is applied to adults and children over the age of 1 month a thin layer to the affected skin open 3-4 times a day to achieve a positive clinical outcome. Åhe cream can be applied under the bandage 1-2 times a day. The duration of treatment is individual, depending on the type and severity of the disease, it usually lasts for 1-2 weeks. Applying the drug within 3+ weeks is not recommended, while the duration of treatment in children must not exceed 5 days.
Fusidic acid contraindications
In any hypersensitivity manifestations fusidic acid treatment should be abandoned. The cream treatment in case of rosacea, perioral dermatitis, viral skin lesions (caused by herpes simplex virus, smallpox), skin lesions, fungi or Mycobacterium tuberculosis infections of the scalp must not be initiated. In case of increased sensitivity to the drug, dermatosis and dermatitis the treatment course should be ceased. Using the medication in children under the age of 1 month is not recommended.
The preparation should used with caution in patients with liver diseases. In severe infection and the need for long-term therapy fusidic acid should be combined with the antibiotic penicillin-or tetracycline. To reduce the severity of dyspepsia while taking the drug into tablets drinking milk is recommended.
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