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Hytrin (Terazosin)


Hytrin represents a blocker of peripheral postsynaptic a1-adrenergic receptors. a1-adrenoceptor blocks prostate and bladder neck smooth muscle , helping to normalize urination in those suffering from benign prostatic hyperplasia. In cause of dilation of arterioles and venules, reduces peripheral vascular resistance and venous return to the heart, thereby reducing blood pressure.

The hypotensive action starts after 15 minutes after ingestion (a single dose is taken into account). The duration of the antihypertensive effect is equal to 24 hours. The maximum effect in a single dose is achieved within 2-3 hours. Maximum hypotensive effect is achieved after 6-8 weeks of therapy. With prolonged use of blood pressure reduction, as a rule, the development of reflex tachycardia doesn’t occur. The preparation promotes the normalization of lipid metabolism: it reduces cholesterol, triglycerides and lipoproteins of low and very low density levels, while increasing the amount of high density lipoproteins. The systematic use of medication marked regression of left ventricular hypertrophy.

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Hytrin pharmacological action

Once inside the body the drug quickly and adequately absorbed from the gastrointestinal tract. The extent of absorption is not dependent on simultaneous ingestion. Cmax in plasma is attained within 1 hour after administration. Plasma protein binding equals to 90-94%. Metabolism and excretion is biotransformed in the liver to form four metabolites, with terazosin among them that provides antihypertensive action.

Hytrin indications for use

The medication is prescribed to deal with nenign prostatic hyperplasia (symptomatic treatment) and hypertesnion.

Hytrin administration

In case of benign prostatic hyperplasia, the starting dose is equal to 1 mg each 24 hourse; and gradually increased to 2-10 mg per day until the optimum effect is achieved. The therapeutic effect is usually observed after 2 weeks after initiation of treatment. In order to achieve a lasting effect treatment should be prolonged to 4-6 weeks. In hypertension cases the drug is prescribed in the initial dose of 1 mg/day at bedtime (the dose can be gradually increased to achieve clinical benefit). Maintenance dose is 1-10 mg 1 time/day, while the maximum daily dose is 20 mg. In case of temporary discontinuation resume treatment in the same way. Duration of the drug’s effect equals 24 hours. If you forgot to take the pill, take it as soon as possible the same day (if it will be the next day, skip the previous dose and go back to the usual regimen; do not double the next dose). Take the medicine as prescribed during the entire treatment period. If you have any side effects stopping treatment is not recommended – consult your doctor first. If the drug has not been taken for several days, it may be necessary again to begin treatment with the initial dose. Inform your doctor of the drugs you take from asthma, colds, allergies, or appetite suppressants. These drugs are in combination with Hytrin can increase blood pressure and cause other complications.

Hytrin precautions

Taking the drug is not recommended in case of hypersensitivity to any component of the drug as well as in case of hypotension. Women during pregnancy breast-feeding periods, as well as children under 16 years old should avoid resorting to Hytrin treatment.

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