Insulin Glargine (Lantus)
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Features of Insulin Glargine (Lantus)
In the healthy human body insulin is produced between meals or at night and after eating. The problem in the pharmaceutical industry was to develop a formulation, which would fully regulate insulin secretion profile over an extended period. So there were long-acting agents, which are added to substances that slow down absorption.
Lantus when you use it is able to accurately simulate the natural stable insulin secretion without pronounced peak efficiency throughout the day. Compensation of diabetes is achieved without risk of hypoglycemia. Moreover, when using this drug, the probability of overdose is reduced.
What is Insulin Glargine (Lantus)?
Lantus - a new, recently developed "background" insulin, intended for once-a-day. This is the first insulin, allowing most patients to achieve smooth and almost constant concentrations of insulin throughout the day. Lantus may be used for diabetes of both first and second type. This is the first long-acting insulin with a stable predictable effect: its effect can be compared with the effect, obtained when using an insulin pump.
Who has developed Lantus and where to buy it?
The appearance of insulin, developed by the French company Sanofi - Aventis, marked the beginning of a new stage in the pharmaceutical market. Being radically new treatment for diabetes, it is recognized as the only human analogue of long-acting insulin. After the introduction, it takes control of blood glucose about 24 hours, thereby enabling improved quality of life for people with type 1 and 2 diabetes.
Lantus, which is an international name of Insulin Glargine, is designed on the latest genetic - engineering base. Geography of Lantus use includes a lot of countries. In Germany and the United States, for example, it is the paramount leader of the basal insulin and about ten years ago, Lantus began the conquest of the British Pharmacological market. This drug ranks high position in sales, and it has the potential to become a leading antidiabetic agent around the globe.
Permanent and unchanging level of a substance in the blood for such a long time is provided due to unique tactics action of Lantus. It also explains the absence of the peak period and delayed absorption of the drug after the injection. Lantus provides tight glycemic control and can minimize the chance of complications in patients with both types of diabetes.
How to adjust the dose of Lantus ?
One of the remarkable properties of Lantus is that it is not difficult to pick up the dose. Since its action is smooth and stable over 24 hours, then the dose is gradually increased up until the fasting glucose level (before breakfast) becomes normal. If marked nocturnal hypoglycemia (not related to the action of short-acting insulin, received in the evening), the dose of Lantus, on the contrary, should be gradually lowered to the disappearance of these phenomena. Lantus dose efficiency can be controlled by passing one of the main meals, but the main criterion, by which you can assess the accuracy of selected dose - it is a stable, steady blood sugar level overnight.
Composition and structure of Insulin Glargine (Lantus)
A preparation Lantus is administered via a syringe-pens. Each ml of solution contains 3.6378 mg insulin glargine - this dose is similar to 100 units of human insulin.
The Lantus solution is transparent, colorless and contains zinc chloride, glycerol (85%), sodium hydroxide, hydrochloric acid, water for injection.
Lantus is released and sold in three forms:
- Solution for subcutaneous injection in cartridge systems OptiClik. Carton pack contains of 5 systems for syringe-pens - OptiClik, in a single cartridge of colorless glass, 3 ml.
- Solution for subcutaneous injection in cartridge systems OptiPen. Carton pack contains of 5 cartridges.
- SoloSTAR - solution for subcutaneous injection in a syringe - pens SoloSTAR.
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