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Promethazine breaks, but doesn’t block histamine action - the substance in human body that causes swelling, itching, sneezing, lacrimation, urticaria, and an array of other symptoms of allergic reactions. It also possesses anticholinergic effect, i.e., it blocks the transmission of certain nerve impulses, which in turn leads to smooth muscle relaxation, which controls the activity of the bladder, stomach, intestine, lung and other organs. This effect helps to relieve the symptoms of motion sickness, nausea, symptoms of gastrointestinal disorders, and reduce anxiety. The preparation boasts noteworthy efficiency and typically used as a drug of the first choice.

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Indications for use

The medication is prescribed to eliminate symptomatic manifestations of hay fever and a range of other allergic reactions. The remedy is also used to prevent motion sickness and and treatment, nausea, vomiting and insomnia.

The dosage and frequency of use

Adults are prescribed 12.5-25 mg of medication 3-4 times in the daytime and 25-50 mg per night (the maximum single dose is 75-mg, the daily - 500 mg). Nausea and vomiting, early 25 mg, and then, 12.5-25 mg every 4-6 hours. Babies: aged 2-6 years, 12.5 mg, 6-14 years old, 25 mg 3-4 times day. To prevent motion sickness syndrome, the preparation is consumed an hour before the trip: an adult-25-50 mg, children 10-20 mg. The speed of action is observed within the 15-60 minutes after perioral administration; and around 20 minutes after injection.

Duration of action

Promethazine effect lasts for 12 hours. If you’ve accidently skipped the intake return to the course as soon as possible. If the break doesn’t equal days (or even long hours), you should avoid doubling the dose. If the period equals several days, you should better correct your dose

Cancelling the course

You can stop taking the medication ahead of scheduled time, if you feel significant improvement. To reduce stomach irritation the medication is highly recommended to be taken with plenty of food or milk. If you have to pass allergological tests, cease promethazine treatment 4 days prior to them, and notify your treating doctor. During treatment, false-positive test results for pregnancy are possible.


The preparation is appointed with caution in case of hypersensitivity (including to other phenothiazines), alcohol intoxication, liver failure, jaundice, prostatic hypertrophy, predisposition to urinary retention, bladder neck stenosis, angle-closure glaucoma, peptic ulcer with pyloroduodenal obstruction, diseases of the lower respiratory tract, epilepsy syndrome sleep apnea, Reye's syndrome, pregnancy, children (up to 2 years), and the elderly. Taking the medication during lactation period is not recommended, yet the potential benefits may level the relatively risks of damage to the fetus. Before you enroll in the treatment course, consult your doctor to pick up the optimal administration regimen.

Side effects

The medication may cause sore throat, fever, unusual fatigue, bleeding and bruising. In this cases you should seek for immediate medical attention. Drowsiness and mucus thickening take place more frequently; blurred vision, confusion, difficulty or painful urination occur more rarely. Dizziness, dry mouth, nose and throat, increased skin sensitivity to sunlight, loss of consciousness, sweating, loss of appetite, ringing or noise in the ears, skin rashes, heart palpitations, unusual excitability and irritability may also manifest.

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