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Staphylococcus aureus is one of the priorities of infections of varying severity in ambulatory patients. According to the National Commission for the control of nosocomial infections (NNIS, USA), S. aureus is the cause of 12% of all nosocomial infections in the U.S., 19% of post-operative wound infections, 16% infections of angiogenic and 20% of nosocomial pneumonia.
When detected or suspected infection caused by MRSA, in-hospital, the number one drug is glycopeptide antibiotics, especially Vancomycin or brand Vanlid.
This antibiotic is used in world clinical practice since 1958.
Why is Vancomycin preferable among doctors and patients?
Vancomycin, natural tricyclic glycopeptide antibiotic, was isolated in 1950, when the disastrous rise of resistance S. aureus to penicillin was undertaken wide-ranging search for a new highly active antistaphylococcal drug.
The drug is effective and easy blocks the synthesis of the cell wall of gram-positive microorganisms: Staphylococcus, Streptococcus (including strains resistant to penicillin), Corynebacterium, Clostridium. Besides, drug-resistant gram-negative bacteria, mycobacteria, fungi, viruses, protozoa and any cross-resistance with other antibiotics - vancomycin can help here.
Immediately after the approval by the FDA in 1958, Vancomycin have been widely used all over the world, but in 2-3 years have been invented methicillin, and then cephalosporins and lincomycin. This has led to a dramatic reduction in the use of Vancomycin. Over the next 20 years, the drug is used primarily for the treatment of staphylococcal infections in patients with severe allergic reactions to penicillin.
What are the indications and contraindications for the use of Vancomycin?
Vanlid is used in infections, caused by Staphylococcus golden, especially nosocomial, sepsis, endocarditis, pneumonia, lung abscesses, osteomyelitis, meningitis, pseudomembranous colitis.
Contraindications to Vancomycin are the standard ones: hypersensitivity, pregnancy (first trimester), lactation, cochlear neuritis, severe renal failure.
Microbiological criteria are important for the prediction of clinical efficacy, therefore, before the use of antibiotics determine sensitivity to selected pathogens.
Clinical: early (1 - 2 days) - a subjective assessment of the patient on treatment outcomes, temperature reaction; later - confirmation of bacterial eradication, instrumental and laboratory confirmation of recovery.
How to take Vancomycin and avoid side effects?
Ordinarily, Vancomycin is administered only intravenously (IV / IM injections are painful) at a rate not exceeding 10 mg / min, the duration of infusion should be no less than 60 minutes. Adults are prescribed 0.5 g 4 times or 1 g 2 times a day. Newborns - 15mg/kg followed by 10mg/kg body weight every 12 hours, in children aged 1 month is applied the same dose every 8 hours, for children older than one month - average daily dose is 40mg/kg. When pseudomembranous colitis, Vancomycin is administered orally as a solution in 30 ml of water: adults daily dose is 0.5-2 g 3-4 times per day, children - 0.04 g / kg (not exceed 2 grams per day) 3-4 times a day. Duration of treatment - 7-10 days.
When you start treatment with Vancomycin turn to the doctor to be informed about its possible side effects and complications. Among them were noticed: thrombophlebitis, seal veins at the injection site, nausea, vomiting, diarrhea, dizziness, tinnitus, eosinophilia, hearing loss, kidney failure, thrombocytopenia, in rare cases - agranulocytosis, allergic reactions (itching, hives, rash, fever, fever, dermatitis, anaphylactic shock). With the rapid introduction of Vancomycin may decrease blood pressure, shortness of breath.
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