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Zestoretic (Hydrochlorothiazide)


Zestoretic is a combined medical product for the treatment of the chronic arterial hypertension. This medication includes two active ingredients, i.e. hydrochlorothiazide and lisinopril, and they have a similar pharmacological action but slightly different effect.

Lisinopril dilates the arteries in a greater degree than veins. It improves the blood supply of stunned myocardium, reduces the pressure in the pulmonary capillaries, and also increases a tolerance of the cardiovascular system to heavy loads as a result of the increase of the arterial pressure.

Hydrochlorothiazide is a thiazide diuretic of the middle strength. It causes the removal of the excess liquid from the body, and at the same time the amount of the harmful components is reduced which indirectly or directly affect the level of the arterial pressure. The diuretic effect develops in 1-2 hours, reaches maximum in 4 hours and acts for about 10-12 hours, and this provides a long-term normalization of the arterial pressure in comparison with other drugs for the treatment of hypertension.

A complex effect of Zestoretic to the body allows to fight both sharp attacks of hypertension and chronic type of the disease preventing relapses and other painful conditions which may lead to the stroke. Also, this drug may be taken during chronic heart failure, diabetes insipidus, and for prophylaxis of the kidney formation in the urinary tracts.

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Zestoretic tablets should be taken orally with a plenty of liquid, and it is advisable to do it before eating. This drug is calculated on the long-term course of the treatment and ineffective for arresting of the sharp attacks of the hypertensive crisis.

Usually, patients are prescribed one tablet a day which contains 10 mg of lisinopril and 12.5 mg of hydrochlorothiazide. For severe conditions the dose may be increased by two times. The adjustment of the dose must be done only under the supervision of the qualified doctor who will be able to estimate your health condition after taking this medication.


- Zestoretic is contraindicated for the use by patients with diseases of kidney when there are difficulties with urination. Also, it is necessary to refuse from the use of this drug if you have increased sensitivity to the active ingredients of the drug.

- The drug is taken with caution in case of: glaucoma, asthma, gout, lupus, pancreatic diabetes, and diseases of liver.

- The use of this medication is highly not recommended during pregnancy.

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